With the added 12th game, I would want to add a conference game so that there is only one team out of the rotation, rather than two, leaving three OOC games: one the annual home opener vs the in-state MAC team for alumni band day, one vs a Top-10 caliber marquee team, and one vs a Top-25 level team from a different BCS conference, or alternately a top tier non-BCS "mid major" that you can reliably predict will be competitive, such as a Fresno or Boise or BYU or TCU or some-such.
Pushing around YSU and Akron and Kent all in the same season does not prepare the team or make them better. They face tougher competition in the jersey scrimmage.
I would not want to see any series with a lower tier SEC team such as UK, Vandy, or Ole Miss until the team gets over that SEC hump by beating one of the big boys. Otherwise, scheduling one of the doormats will just be perceived negatively throughout the country. If USC can play a Top-5/10 level opponent every year and Notre Dame, there is no reason OSU cannot/should not be doing the same.
It's fashionable to hate USC, but after the behind-the-woodshed beat downs they've laid on teams like Arkansas, Auburn, Virginia Tech, etc ... plus Notre Dame every year for the past six or seven years, they have earned the right to be in the national title discussion and receive the benefit of the doubt every year until PC leaves.