To me the talent advantage along both lines is undeniable so big advantage OSU there.
Offensively, styles make the fight and unfortunately for TCU they have the wrong style to fight OSU. They run the spread, read option offense that is pretty much the standard today. OSU's defense is built for, and used to, that. The recipe for hurting OSU's defense is pro style and have a quick release, highly accurate QB who can hit TE's, RB's and quick slants to receivers while under pressure. That is NOT what the TCU kid brings to the table.
OSU offense vs TCU defense will come down to Dwayne Haskins vs the TCU DC in a contest of recognition vs disguise imo. TCU knows they have to rely on their quickness and confusing the young QB. No way they can just line up man for man. Similar to JT vs Bud Foster in 2014 imo. Let us pray for a better result (and I think there will be).
OSU has better players and more of them. It may take a little while but eventually that will prove out and the final score will not be all that close.