I think it's safe to say that no player will break Wilt's record if he does not play all 4 quarters. With that said, when players nowadays start getting up there in the point totals, they will usually be pulled around the 3rd quarter or so, assuming you have a good lead (which you usually do when a player is on fire like that). No player will have a chance to break Wilt's record if this keeps happening. After Kobe scored his 81 last night, it showed that a player could take a stab at it if they get the minutes, but unless they get to play the whole game Wilt will keep his record.
So the question is, is it fair to give a player a chance to get the record if he has the oppurtunity, even if it means have him keep shooting in a blowout game?