Coronavirus (COVID-19) is too exciting for adults to discuss (CLOSED)

[sparcboxbuck]

Conclusions:
In this preliminary study of adult outpatients with symptomatic COVID-19, patients treated with fluvoxamine, compared with placebo, had a lower likelihood of clinical deterioration over 15 days. However, the study is limited by a small sample size and short follow-up duration, and determination of clinical efficacy would require larger randomized trials with more definitive outcome measures.

I just looked it up. It is a serotonin reuptake inhibitor. Not exactly sure how that would impact a virus. Great if it works. The headaches and impotence are probably better than death. No joke, I’d be careful with the dosage if you try it. Fucking with your brain chemistry may be worse than a mild case of the covids.

 

[heisman]

I just looked it up. It is a serotonin reuptake inhibitor. Not exactly sure how that would impact a virus. Great if it works. The headaches and impotence are probably better than death. No joke, I’d be careful with the dosage if you try it. Fucking with your brain chemistry may be worse than a mild case of the covids.

No, you’d have to have a screw loose to take this shit....literally. Hahaha!!

 

[Taosman]

“Children tend to not become as severely ill as adults [from Covid-19] but they can still become ill and some have tragically died,” Dr Leana Wen, a public health expert, told the Associated Press. “Children can also be vectors of transmission, and getting children vaccinated is important.”
https://www.theguardian.com/us-news/2021/jan/29/us-children-covid-vaccination-fauci

 

[jwinslow]

 

[ScriptOhio]

Just signed up for Monday, 1 Feb 2021 at the Schottenstein Center. I want to get in this nurse's line:

An opening for vaccine was available at Mt Carmel East (closer to home); so I cancelled the Schottenstein Center and scheduled there. One shot down and one to go:

Apparently the second Pfizer shot is actually 3 weeks ± 4 days. I have the send shot scheduled for the 18th. Let's get it over with as soon as possible.

P.S. My nurse was really nice and the shot was painless; however, I didn't see any nurse resembling the above picture working at Mt Carmel East.

 

[Hstead]

They just have to politicize everything. It is a little unfair to Trump when it was his administration that rushed through the process in record setting display to get the vaccines on the market. SMDH

 

[exhawg]

They just have to politicize everything. It is a little unfair to Trump when it was his administration that rushed through the process in record setting display to get the vaccines on the market. SMDH

I don't think the bashing has anything to do with getting the vaccines ready quickly, just every other covid related decision he made. I don't know that I buy the vaccines would have been slower with someone else in the WH. The whole world was rushing vaccines. Trump's only honest covid comments were to Woodward. More people died than would have if he had started calls for masks and social distancing in February when he knew it was going to get bad, but called it a hoax to bring him down. I keep saying it but Trump was the only person with enough pull to get everyone to wear masks and he refused.

 

[sparcboxbuck]

So, I’m confused. We can now discuss Covid as being comparable to the flu?






(Running for cover)

 

[Hstead]

It doesn't matter what administration is in charge, masks, social distancing, lockdowns, etc, the virus is going to virus. I guess Trump is responsible for Europe's deaths too? Compare Florida to Cali. Cali has been locked down forever and Florida has been quite "open". Their numbers are almost identical when it comes to deaths and infections per 100K.

https://www.worldometers.info/coronavirus/worldwide-graphs/#europe-usa-deaths

 

[maximumblitz]

How do you get a script for this? It’s not an over the counter med.

Right. My thinking is to call my doctor as soon as I get covid. In the phase 2 study and in the phase 3 study, you only have to start taking the medicine until after you have the virus. That is soon enough. From what I have read, the key to corona happens around 8 days in, when it can take a huge turn for the worse.

I would think that whether your doctor wants to prescribe for off label depends on how many risk factors for complications you have (age, comorbidities, etc). Or not. The doctor in the press release prescribed it for those patients that wanted it.

 

[maximumblitz]

Do you know anything about how this works? I know that things like serotonin uptake inhibitors can cause people headaches. FWIW.

From what I have read, the medicine just happens to have anti-inflammatory properties. And from what I have read, the hospitalizations and deaths come when the lungs and blood vessels get inflamed.

The designers of the medicine didn't set out to do it. It was just an empirical results.

 

[maximumblitz]

Conclusions:
In this preliminary study of adult outpatients with symptomatic COVID-19, patients treated with fluvoxamine, compared with placebo, had a lower likelihood of clinical deterioration over 15 days. However, the study is limited by a small sample size and short follow-up duration, and determination of clinical efficacy would require larger randomized trials with more definitive outcome measures.

Yup, exactly right. The gold standard of a triple blind, large, phase 3 trial does not currently exist.

Suppose you have a doctor that treats corona all the time in hospitals and is a pulmonologist that sees all the bad cases. Suppose they talk to patient X and tells them based on science and experience that they are at high risk of dieing if they get C19, due to comorbidities (age, weight, smoking, ......, .....). One can either wait for the phase 3 trial to complete, or go off label and prescribe fluvoxamine. It is all about weighing risks. All medicines have risks. Doctors write off label scripts all the time (e.g. use medicine approved for a new use for which no phase 3 trial exists). Sure, a doctor can be completely safe and let the patient die, as expected. Lots of doctors do that. Or the doctor can write off script and take a chance of the medicine not helping, or even hurting, due to some other known side effect.

Here is a Washington Post article that discusses "the balance between ultra rigorous trials and trying to keep patients alive":
https://www.washingtonpost.com/outlook/2021/01/27/covid-19-experimental-treatments/

 

[maximumblitz]

I just looked it up. It is a serotonin reuptake inhibitor. Not exactly sure how that would impact a virus. Great if it works. The headaches and impotence are probably better than death. No joke, I’d be careful with the dosage if you try it. Fucking with your brain chemistry may be worse than a mild case of the covids.

Right, if one knew in advance it would stay as a mild case, no way one would never want to take fluvoxamine. But one doesn't know until around day 8 thru 11, from what I have read. risks factors and age may inform the decision.

In the observational study, if I recall, something like 60% of the people at the race track said "no, I don't want it". That changed after folks who did not take it landed in the hospital or died, while no one who took it landed in the hospital. A larger percentage then wanted to take it. Others decided to wait for the phase 3 study.

 

[maximumblitz]

I agree with the NYT.

In fact, I read the JNJ press release a couple times. And I will quote it here to keep myself honest and so that all yawls can tell me if I have gone crazy:

85% Effective Overall in Preventing Severe Disease and Demonstrated Complete Protection Against COVID-19 related Hospitalization and Death as of Day 28

Okay, so you get the JNJ vaccine 28 days ahead of when you get corona, then you know (pretty much) that you will not end up in the hospital and you will not die.

Sign me up! Main line that stuff into me!

Eventually, someone will die after 28 days, but hey, 44K successes works for me. Sign me up.

The thing that is not widely discussed is that JNJ is still studying what happens if they give a second dose about 2 months later (or was it 4 months later). My guess is that it is going to be VERY successful after that.

The JNJ vaccine rocks, as near as I can tell.

 

[heisman]

Yup, exactly right. The gold standard of a triple blind, large, phase 3 trial does not currently exist.

Suppose you have a doctor that treats corona all the time in hospitals and is a pulmonologist that sees all the bad cases. Suppose they talk to patient X and tells them based on science and experience that they are at high risk of dieing if they get C19, due to comorbidities (age, weight, smoking, ......, .....). One can either wait for the phase 3 trial to complete, or go off label and prescribe fluvoxamine. It is all about weighing risks. All medicines have risks. Doctors write off label scripts all the time (e.g. use medicine approved for a new use for which no phase 3 trial exists). Sure, a doctor can be completely safe and let the patient die, as expected. Lots of doctors do that. Or the doctor can write off script and take a chance of the medicine not helping, or even hurting, due to some other known side effect.

Here is a Washington Post article that discusses "the balance between ultra rigorous trials and trying to keep patients alive":
https://www.washingtonpost.com/outlook/2021/01/27/covid-19-experimental-treatments/

No, I understood. It was the comment either you or someone made about stocking up on this "to be safe." It's irresponsible to say the least.

Also, just to be clear, the doctors aren't treating "Corona", they are treating inflammation. Nothing more, nothing less. So, technically, they are finding ways to REDUCE your body's ability to fight the virus. Hope that makes sense.