Well, attrition is starting in already. Trevor Stephan is likely out for the year. Gavin Williams will start the season on the IL. Karinchak looks like he'll also start the season on the IL and Sam Hentges' middle finger is up in the air. You could say Espino, too, but I haven't thought that he's a guy to count on for awhile now.
The good news is that maybe the youngsters will get a chance. I'm a big Joey Cantillo fan and I think Will Dion is a sleeper to watch for. On the offensive side, it certainly seems like Kyle Manzardo is chugging along towards making the opening day roster. There's some buzz that Chase DeLauter might, just maybe, make the opening day roster. He didn't get a big league camp invite, but came over when they needed some extras and has stuck around. Lastly, Angel Martinez could be a darkhorse to win the SS job. While you never should put too much weight in Spring Training, neither Arias or Rocchio have looked good so far, while Martinez has been very consistent.