Holy Buckeye gets my vote for all reasons that others have posted. One catch that I'll always remember was Terry Glenn slicing up the ND defense and sprinting to the end zone. It didn't have the significance of HB or The Catch, or any of the others listed, but that game sort of re-announced the return of Buckeye football to the national stage. Plus, I always enjoy the Bucks sticking it to the Domers.
Miller to Smith may one day be viewed as a turning point for the program (depends on how the team finishes this season). I stated this in another thread, but could you imagine the mood around the program had they not pulled this off? Instead, the fan base is rejuvenated, recruiting got a much needed shot in the arm, and I hope that the team feeds off of a big win. This season suddenly has possibilities instead of disaster. After all of the kicks to the groin that this program has received recently, a win like this was sorely needed.