I wouldn't go that far.
Santonio Holmes
Year Team G GS Rec Yards AVG LG TD
2006 Pittsburgh Steelers 16 4 49 824 16.8 67T 2
2007 Pittsburgh Steelers 13 13 52 942 18.1 83 8
2008 Pittsburgh Steelers 15 15 55 821 14.9 48 5
2009 Pittsburgh Steelers 16 16 79 1,248 15.8 57 5
2010 New York Jets 12 10 52 746 14.3 52 6
Totals (5 years) 287 4,581 16.0 83 26
Braylon Edwards
Year Team G GS Rec Yards AVG LG TD
2005 Cleveland Browns 10 7 32 512 16.0 80T 3
2006 Cleveland Browns 16 15 61 884 14.5 75 6
2007 Cleveland Browns 16 16 80 1,289 16.1 78T 16
2008 Cleveland Browns 16 16 55 873 15.9 70 3
2009 Cleveland Browns 4 4 10 139 13.9 24 0
2009 New York Jets 12 11 35 541 15.5 65T 4
2010 New York Jets 16 15 53 904 17.1 74T 7
Totals (6 years) 326 5,142 15.8 80 39
While Edwards has played one more season than Holmes, Edwards' career averages are every bit as good as Holmes'. In fact, Edwards scored 25 of his 39 touchdowns in his first 3 seasons, which is one less than Holmes has scored in his 5 seasons.
Also, while Holmes has the upper hand on Manningham as of right now in terms of career totals, I would argue that Manningham is more explosive. Holmes recorded an 83 yard catch. the longest of his career, in 2007. Last season, Manningham two scored touchdowns longer that in back to back weeks. After burning the eventual Super Bowl champion Green Bay Packers for a 85 yard score, he burnt Washington Redskin cornerback DeAngelo Hall, arguably one of the best in the league today, for a 92 yard TD, which went down as the longest touchdown catch of 2010. All of Manningham's 14 career came in the last two seasons as the third wide receiver. With Steve Smith leavng the NY Giants for Philly, (personally, I always thought that Manningham was better, but I'm admittedly biased), Manningham's prodution will likely increase if he stays healthy.
While Holmes Super Bowl MVP Award is nothing short of impressive, to say that he's head & shoulders above all of Michigan's receivers is a tad bit far fetched, especially compared to Edwards.
