My mid-80s after school ritual was to run home from school to watch GI Joe and The Transformers, then I'd switch to Nickelodeon to watch Dangermouse.
In high school I would watch Tiny Toons Adventures during breakfast. That show was very clever -- and despite being drawn in bright pastel colors to appeal to 8 year olds the humor was definately targeted to older audiences.
Now, at night (for myself) I'll watch South Park and Drawn Together. When the 4-year old is still awake and mommy won't let us go outside, we'll watch Teen Titans, The Grimm Adventures of Billy & Mandy, and The Fairly Odd Parents.