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Coronavirus (COVID-19) is too exciting for adults to discuss (CLOSED)

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AKAK said:
You're not wrong from the perspective if they they to make vaccines out of other coronaviruses and it only elicits a TCell response and not. Bcell response, indeed you won't have a very good vaccine.

That misses a couple other implications here around clinical outcomes and herd immunity modeling. Themes IbI have posting about for a long time in this thread.

But I mean I can stop posting and you can see interpret everything for us.
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Didn't mean to offend, was just trying to clarify my own posts. You clearly have a better understanding of this stuff than I do.
 
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DaddyBigBucks said:
Didn't mean to offend, was just trying to clarify my own posts. You clearly have a better understanding of this stuff than I do.
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What I am trying to get at is (for no real reason other than I'm curious) is memory T cell response over lifetimes. I mean I get this CD4 (or 8 or whatever) being relatively short lived, but obviously vaccines (for whatever) generally last a lot longer than that... (And as you get older your ability to make use of said memory probably declines.

I don't really understand shit, most likely, its just a lot of different avenues of importance in play. I just got interested in these various ones back in the "OMFGZ! Peoples are getting infected over and over" days. (Way back in June or whatever :lol:)
 
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Bucklion said:
That’s only in Phase I/II...if they are saying that could be available before a vaccine, that is not good news from a temporal perspective.
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Safety aside (that was fun wasn't it)... Uh, I think someone is in phase 3 with the same candidate now... And... Its therapeutic right? So its go find sick people and see if it works... Which is something different than inocculate 30k people and send them into the wild and see how many get sick over months. (That said production capacity seems like a problem)
 
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Got to get multiple treatments going to buy time for a vaccine. Cycle the sick out of hospitals faster to take pressure off the system. We are in a race against covid blowing up the college football season. . It would be very disheartening for the college football season to get blown up now.
 
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ORD_Buckeye said:
A peer reviewed study published in Lancet has found brain damage in 55% of recovered COVID patients with no differences observed between moderate and high symptom patients.

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Holy Crap

Seriously reducing the brain capacity of millions of people...

The opportunity-cost of that is potentially history-altering; but it will be invisible. No one will know how the world would have looked if COVID-19 hadn't happened; but it would have been a lot different
 
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ORD_Buckeye said:
A peer reviewed study published in Lancet has found brain damage in 55% of recovered COVID patients with no differences observed between moderate and high symptom patients.
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No it didn't.

Here's same dude walking back as far as his little sky is falling ass will go.



55% of patients reported Symptoms including fatigue, one could correlate with neurological damage. They did not establish 55% were brain damaged. I mean I get he's trying to use the word "manifest" to paper over that difference, but I'm fatigued right now.... In a few minutes I'm gonna stand up and I will probably be dizzy... And most likely I will have to find my car keys rather than remember where I put them.

Bar-Yam is a smart guy but he's Andy Slavitting this one.
 
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AKAK said:
No it didn't.

Here's same dude walking back as far as his little sky is falling ass will go.



55% of patients reported Symptoms including fatigue, one could correlate with neurological damage. They did not establish 55% were brain damaged. I mean I get he's trying to use the word "manifest" to paper over that difference, but I'm fatigued right now.... In a few minutes I'm gonna stand up and I will probably be dizzy... And most likely I will have to find my car keys rather than remember where I put them.

Bar-Yam is a smart guy but he's Andy Slavitting this one.
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Thanks for the clarification on this. Maybe I should look at the studies before I comment on the tweeted "results" lol
 
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AKAK said:
No it didn't.

Here's same dude walking back as far as his little sky is falling ass will go.



55% of patients reported Symptoms including fatigue, one could correlate with neurological damage. They did not establish 55% were brain damaged. I mean I get he's trying to use the word "manifest" to paper over that difference, but I'm fatigued right now.... In a few minutes I'm gonna stand up and I will probably be dizzy... And most likely I will have to find my car keys rather than remember where I put them.

Bar-Yam is a smart guy but he's Andy Slavitting this one.
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Correlation does not equal causation, but this study isn’t nothing either.
 
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Bucklion said:
Correlation does not equal causation, but this study isn’t nothing either.
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If its a first step.to say, "we really should keep an eye on this to see if covid patients have different neurological outcomes over time over populations" yep, ok. No problem.

The intent though was to scream "55% of people have brain damage!!!!" By a guy who is and has advocated loudly for a hard quarantine. He goes on to imply that its increasing the risks for Alzheimer's, etc.
 
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AKAK said:
If its a first step.to say, "we really should keep an eye on this to see if covid patients have different neurological outcomes over time over populations" yep, ok. No problem.

The intent though was to scream "55% of people have brain damage!!!!" By a guy who is and has advocated loudly for a hard quarantine. He goes on to imply that its increasing the risks for Alzheimer's, etc.
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AKAK said:
If its a first step.to say, "we really should keep an eye on this to see if covid patients have different neurological outcomes over time over populations" yep, ok. No problem.

The intent though was to scream "55% of people have brain damage!!!!" By a guy who is and has advocated loudly for a hard quarantine. He goes on to imply that its increasing the risks for Alzheimer's, etc.
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Part of the problem on the Neuro side too is that it wasn’t considered to be all that critical initially. Thus, many autopsies didn’t even collect the brain, so there is a shortage of tissue to assess the pathological side and match the findings with these types of MRI results.
 
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Bucklion said:
Part of the problem on the Neuro side too is that it wasn’t considered to be all that critical initially. Thus, many autopsies didn’t even collect the brain, so there is a shortage of tissue to assess the pathological side and match the findings with these types of MRI results.
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Where did you get this brain?

Someone named Abby Normal.

Side note, and nothing about this in particular, and this gets back to Mili's question about why a vaccine for this and not MERS or SARS.... And of course its $. Which is to say, "he I want to do ___ related to covid 19". Cash falls.from sky for your study/treatment/vaccine/social impact survey/etc.

We're going to end up knowing more about this virus than any coronavirus ever and probably.any virus thats not HIV. (And maybe even that). And its probably likely that lots of pathogens do, to some degree, a lot of similar shit... We just don't look... Anyway... Enough virus for me today.
 
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