Disclaimer: What follows is from spreadsheets, not opinion. It is not a recommendation for how to bet your v$.
Differential Statistical Analysis is defined in the Stats thread which is currently on the front page of the Buckeye Football board. It provides a pair of "predictions" for yards and points for each team.
Northwestern: 35.8 to 40.6 points and 478 to 488 yards
Indiana: 24.6 to 25.0 points and 385 to 388 yards