I bet House does something that threatens his life in the process of a mysterious sickness popping up at their hospital, which will be diagnosed incorrectly once or twice (probably as lupus), then House will have an epiphany while talking to Wilson and solve it, and it'll be an easy fix, like they need to repaint the bedroom door so it doesn't have lead in it.
Cameron and Chase will have an awkward "are we together or not?" moment, 13 and the black dude will have the same, and Cuddy (or however it's spelled) will have too tight of clothes and her boobs will be nearly exposed.