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Another sexual issue.

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The article doesn't mention it, but a small part of every population is usually at risk for a vaccine giving them the infection it attempts to vaccinate against. I wonder if this is the case. Are they going to give cervical cancer to some 6 year old girl?
 
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FindlayBucks said:
The article doesn't mention it, but a small part of every population is usually at risk for a vaccine giving them the infection it attempts to vaccinate against. I wonder if this is the case. Are they going to give cervical cancer to some 6 year old girl?
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Here's the abstract on this vaccine.

Full Text here (It's premium content :( )

The HPV-16 L1 virus-like–particle vaccine (Merck Research<sup> </sup>Laboratories) consists of highly purified virus-like particles<sup> </sup>of the L1 capsid of HPV-16. The HPV-16 L1 polypeptide is expressed<sup> </sup>in yeast (Saccharomyces cerevisiae). Virus-like particles are<sup> </sup>isolated with the use of standard techniques to achieve a purity<sup> </sup>of more than 97 percent and adsorbed onto amorphous aluminum<sup> </sup>hydroxyphosphate sulfate adjuvant without preservative. The<sup> </sup>HPV-16 vaccine used in this study contained 40 µg of HPV-16<sup> </sup>L1 virus-like particles formulated on 225 µg of aluminum<sup> </sup>adjuvant in a total carrier volume of 0.5 ml. The placebo contained<sup> </sup>225 µg of aluminum adjuvant in a total carrier volume<sup> </sup>of 0.5 ml. Vaccine and placebo were visually indistinguishable.
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If I'm reading this correctly, the Virus-like particles consist only of capsid proteins (the virus coat, or shell) with no DNA or any of the inner workings that make it a replicating, infectious virus. In that case, there would be no risk of infection from the vaccine itself.

As far as side effects, there was no statistical difference between the vaccine and the placebo (although with a sample size of 1200, this is hardly definitive, as a true vaccine release would involve several thousand times as many doses, etc......


Overall, looks fairly good. Only shortcomings I can see on cursory exam are that they only have data for 1.5 years post vaccination, so this may not be a long-term protective vaccine (as in, how many women will want to be injected 3x every couple years to protect from something that's already not a huge threat?). That and the vaccine is only protective against the one strain (although going to a mixed-strain vaccine would likely just be a matter of scale, now that the single strain has been demonstrated effective.)

SOrry. got long-winded.
 
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