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Mizzou -11.5 at Iowa St (ov/un 52.5) 7 ET

http://sports.espn.go.com/ncf/news/story?id=5816819
Austen Arnaud's college career over

AMES, Iowa -- Iowa State says doctors have confirmed that senior quarterback Austen Arnaud's college career is finished.

Arnaud suffered a major knee injury in last week's loss to Colorado and will need total reconstruction of his left knee.

Arnaud was a three-year starter for the Cyclones. He is Iowa State's career leader in completion percentage and ranks second with 6,777 passing yards and 42 touchdown passes.

The Cyclones (5-6, 3-4 Big 12) host No. 15 Missouri (8-2, 4-2) on Saturday, needing a win to become bowl eligible. Backup quarterback Jerome Tiller will start for Iowa State.
 
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